All human tissues processed by C+TBA are exclusively produced in countries that implemented all relevant EU Directives into national legislation or apply it.

That means that they work according to the same high quality standards and on the same level of safety equivalent to those of C+TBA; this also applies to Germany and Austria.

Bone tissue is collected using a standardised collection protocol in certified donor centres or by mobile donation teams. Tissue donations can only be performed based on the written consent of the patient in case of a good health status of the donor as determined by means of highly-selective exclusion criteria.Bone donation is voluntary and is not remunerated.

Cancellous bone regeneration material of living donors is collected after femoral heads resection during hip arthroplasty; cortical and corticocancellous allografts are collected from the femur or distal tibia within a maximum period of 24 h post mortem and after comprehensive medical screening.

After approval of the donor, systematic serological testing is performed. In addition to the legally required examinations, nucleic acid tests (NAT) are performed to facilitate later screening for core and for surface antigens of hepatitis (HBs, HBc) and HI viruses (Ag p-24) in case of non-detectable antibodies (outside the diagnostic range).