Cells+Tissuebank Austria

Magnesitstraße 1, 3500 Krems an der Donau
Phone +43 (0) 2732 76954 - 0 | E-Mail office@ctba.at

Safety and Quality
Our transplants are manufactured to the highest quality standards.
Tailored to individual requirements and a variety of indications.
Health and mobility. Many bone diseases can nowadays be cured with bone allografts. With your donor you can make a difference. 


After preliminary cleaning and shaping, transplants are rinsed with purified water and treated with volatile reagents. Viruses, bacteria and fungi are decreased by at least 6 log levels. Besides the careful selection of the donor tissue at the donor site (medical history) and serological examination, C+TBA’s Allotec® Process stands for highest safety and quality of the transplants.

Cleaning & processing

After initial rough cleaning, the tissue is brought to its final shape (blocks, rings, granules, etc.). Residual blood, cell, and tissue components are then washed out in the ultrasonic bath and fat tissue removed from the cancellous structure of the bone.

During subsequent purification, residual cells are washed out, non-collagen proteins denatured, and the antigenic and/or immunogenic potential reduced. Above all, potential viruses are inactivated and residual bacteria eliminated. During the final oxidative treatment persistent, soluble proteins are denatured, specific non-enveloped viruses and bacterial endospores inactivated thus minimising potential antigenicity. During this step, insoluble collagen remains unchanged.

In addition to the purification with volatile reagents, the tissue is lyophilised. In this tissue-conserving drying process, frozen fluid inside the tissue sublimes to the gaseous phase. During lyophilisation, the structural properties and characteristics of the tissue are preserved which accelerates the incorporation of the transplant.1 The process also yields a residual water content of ≤10%.

Final sterilisation by means of gamma irradiation with 25 to 35 kGy at <50°C ensures a sterility assurance level (SAL) of 10-6 and gentle sterilisation of both product and packaging without structural or functional limitations.

"Chemical cleaning with volatile reagents is performed in order to preserve the biomechanical and biological properties with regard to bone regeneration simultaneously eliminating antigenicity and infection risk."
Monika Pichler - Responsible person 

1. Osbon DB, Lilly GE, Thompson CW et al.. Bone grafts with surface decalcified allogeneic and particulate autologous bone: report of cases. J Oral Surg. 1977 Apr;35(4):276-84.