Infection prophylaxis and the treatment of infections are carried out using antibiotic-loaded bone cements and other antibiotic carriers, among other things. Depending on the indication, different materials are required for local antibiosis in order to ensure a targeted and therefore efficient release of the active substance. In the international literature, the efficacy and duration required for successful therapy are the subject of controversial debate. In particular, the doping of allografts with antibiotics and their use as local antibiotic carriers are discussed. 1, 2, 3
In order to provide an overview of the possibilities for inoculating allograft C+TBA with antibiotics, the handling of allograft C+TBA in this context and corresponding publications are shown in these documents.
1. BUTTARO, Martin A., et al. High active local levels of vancomycin without nephrotoxicity released from impacted bone allografts in 20 revision hip arthroplasties. Acta orthopaedica, 2005, 76th volume, no. 3, p. 336-340
2. BUTTARO, M. A.; PUSSO, R.; PICCALUGA, F. Vancomycin-supplemented impacted bone allografts in infected hip arthroplasty TWO-STAGE REVISION RESULTS. Journal of Bone & Joint Surgery, British Volume, 2005, 87th volume, no. 3, p. 314-319
3. MCLAREN, Alex C. Alternative materials to acrylic bone cement for delivery of depot antibiotics in orthopaedic infections. Clinical orthopaedics and related research, 2004, 427th volume, p. 101-106